Dr. Andrew McGuire is an Associate Professor in the Immunology and Vaccine Development Program within the Vaccine and Infectious Disease Division at Fred Hutch and a member of the Pathogen-Associated Malignancies Integrated Research Center (PAM IRC). He is a molecular and cellular biologist whose work focuses on the design of HIV vaccines. His research centers on developing immunogens – molecules designed to stimulate the immune system to produce protective, neutralizing antibodies that block viral infection. Because HIV mutates rapidly, conventional antibodies often fail to provide durable protection. Dr. McGuire’s work aims to guide the immune system to generate broadly neutralizing antibodies, which are more difficult for HIV to evade and offer protection against diverse viral strains. His laboratory also designs vaccines targeting